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retatrutide weight loss clinical trials Eli Lilly's Phase 3 studies investigating retatrutide, the "triple-G" agonist, have found that long-term use can achieve substantial loss. Read about the work via the link in

Injury and Bone Stress Risk Lower body weight + reduced intake can mean lower bone density over time and increased risk of stress fractures, which may be a concern for high-mileage runners or those with a history of RED-S (Relative Energy Deficiency in Sport)

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The same has not been clearly shown for cholesterol